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KMID : 0604520220480030265
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Journal of the Society of Cosmetic Scientists of Korea
2022 Volume.48 No. 3 p.265 ~ p.273
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Anti-inflammatory Activity of Viscum album var. coloratum In Vitro
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Hong Chang-Eui
Lim Wan-Taek
Lyu Su-Yun
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Abstract
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In this study, we investigated whether Korean mistletoe (Viscum album L. var. coloratum) has anti-inflammatory effects that play key roles in the regulation of pathological mechanism of atopic dermatitis (AD). Four kinds of fractions, hexane (HX), ethyl acetate (EA), butanol (BU), and methylene chloride (MC), were used and RAW264.7 mouse macrophages and RBL-2H3 rat basophils were used to measure various inflammatory markers. EA significantly decreased mRNA expression and protein secretion levels of tumor necrosis factor alpha (TNF-α), interleukin (IL)-6, and IL-4 but HX did not affect these markers. In addition, BU decreased mRNA expressions of IL-4 and IL-6 whereas MC decreased IL-6 and TNF-α mRNA expressions. As a result, Korean mistletoe can show anti-inflammatory effects by inhibiting the secretion of cytokines related to AD, so it is thought that it will be possible to develop functional cosmetics related to this.
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KEYWORD
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Korean mistletoe, Viscum album L. coloratum, anti-inflammation, atopic dermatitis
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